Poster Presentation Joint 2016 COSA and ANZBCTG Annual Scientific Meeting

Contemporary risks of recurrence after adjuvant radiotherapy of patients treated for primary breast cancer (#292)

Greg Mitchell 1 , Conrad Brandt 1 , Kimberley Prince 1 , Michael Francis 2 , Margaret J Rogers 3 , Graham Pitson 2
  1. Department of Surgery, Barwon Health, Geelong, Victoria, Australia
  2. Andrew Love Cancer Centre, Geelong, VIC, Australia
  3. Barwon South Western Region Integrated Cancer Services, Geelong, Australia


Breast cancer treatment outcomes have steadily improved over the last 20 years. Results from randomised studies demonstrate the benefits of radiotherapy following breast conservation and post-mastectomy for selected patients. More recent international results demonstrate continued improvements in loco-regional control. The aim of this study was to determine recurrence rates in a contemporary Australian series and determine if local experience is in keeping with published benchmarks.


This was a retrospective analysis of all breast cancer patients treated with adjuvant radiotherapy in a large regional radiotherapy centre between the years of 2009-2011. Patients with DCIS and neoadjuvant treatment were excluded. All cases were individually reviewed. The 5 year risks of developing local recurrence (LR), loco-regional recurrence (LRR), distant metastases (DM), disease free survival (DFS) and overall survival (OS) were calculated using Kaplan-Meier statistics.


A total of 419 patients received adjuvant radiotherapy during the study period, with 338 courses of whole breast radiotherapy (WBRT) and 83 of post-mastectomy radiotherapy (PMRT). The average age was 60 with a median follow up of 54 months. PMRT patients had higher T and N stage. The 5 year rates of LR and DM following WBRT were 1.6% (CI 0-3.3) and 3.1% (CI 0.9-5.3) with the corresponding rates following PMRT being 2.6% (CI 0-7.4) and 22% (CI 8-34) (there were no isolated regional recurrences). The overall 5 year DFS and OS were 93% (CI 88-97) and 95% (CI 91-98) respectively.


These results provide local documentation of high loco-regional control rates for breast cancer in a contemporary series at relatively early follow up. These improved outcomes likely reflect improvement across diagnosis, surgery, pathology, systemic and local treatments.